Zydone (Hydrocodone & Acetaminophen)


Zydone (Hydrocodone & Acetaminophen) 7.5/400mg pills/tablets:
Zydone (Hydrocodone & Acetaminophen) is a semi-synthetic opioid derived from codeine. Hydrocodone is used orally as a narcotic analgesic and antitussive, often in combination with paracetamol or ibuprofen. Hydrocodone is prescribed predominantly in the United States.
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Buy Zydone (Hydrocodone & Acetaminophen) Online

Buy Zydone (Hydrocodone & Acetaminophen) Online without a prescription for oral administration. These tablets contain hydrocodone, bitartrate, and acetaminophen in the following strengths:

Hydrocodone Bitartrate, USP 5 mg
Acetaminophen, USP 400 mg
Hydrocodone Bitartrate, USP 7.5 mg
Acetaminophen, USP 400 mg

Hydrocodone Bitartrate, USP 10 mg
Acetaminophen, USP 400 mg

In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, crospovidone, microcrystalline cellulose, povidone, pregelatinized starch, and stearic acid. The 5 mg/400 mg strength contains FD&C Yellow No. 10; the 7.5 mg/400 mg strength contains FD&C Blue No. 2; and the 10 mg/400 mg strength contains FD&C Red No. 40.

To buy ZYDONE tablets, you must meet USP Dissolution Test 1.

Hydrocodone bitartrate is an opioid analgesic and antitussive that occurs as fine, white crystals or as a crystalline powder. It is affected by light. The chemical name is 4,5-epoxy-3-methoxy-17-methyl morphinan-6-one tartrate (1:1) hydrate (2:5). It has the following structural formula:

Hydrocodone Bitartrate Structural Formula

Acetaminophen, 4’-Hydroxyacetanilide, a slightly bitter, white, odorless, crystalline powder, is a non-opiate, non-salicylate analgesic and antipyretic. It has the following structural formula:

Clinical theory

Hydrocodone is a semisynthetic opioid analgesic and antitussive with multiple actions that are qualitatively similar to those of codeine. Most of these involve the central nervous system and smooth muscle. The precise mechanism of action of hydrocodone and other opiates is not known, although it is believed to relate to the existence of opiate receptors in the central nervous system. In addition to analgesia, opioids may produce drowsiness, changes in mood, and mental clouding.

The analgesic action of acetaminophen involves peripheral influences, but the specific mechanism is as yet undetermined. Antipyretic activity is mediated through hypothalamic heat-regulating centers. Acetaminophen inhibits prostaglandin synthetase. Therapeutic doses of acetaminophen have negligible effects on the cardiovascular or respiratory systems; toxic doses may cause circulatory failure and rapid, shallow breathing.


Respiratory Depression

At high doses or in sensitive patients, hydrocodone may produce dose-related respiratory depression by acting directly on the brain stem respiratory center. Hydrocodone also affects the center that controls respiratory rhythm and may produce irregular and periodic breathing.

Head Injury and Increased Intracranial Pressure

The respiratory depressant effects of opioids and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggerated in the presence of a head injury, other intracranial lesions, or a preexisting increase in intracranial pressure. Furthermore, opioids produce adverse reactions that may obscure the clinical course of patients with head injuries.

Acute Abdominal Conditions

The administration of opioids may obscure the diagnosis or clinical course of patients with acute abdominal conditions.

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